WebThe dose-dependency of phenprocoumon disposition was determined in rats by iv administration of 0.1 and 1.0 mg/kg doses to separate groups of animals. The intrinsic … WebAcenocoumarol (ACE), phenprocoumon (PPC) and warfarin (WFN) are commonly used for the causal or prophylactic oral treatment of venous and arterial thrombosis (vitamin …

Pharmakokinetik und Metabolismus von Phenprocoumon — …

Mechanism of action Phenprocoumon is an inhibitor of the enzyme vitamin K epoxide reductase (VKOR). Vitamin K is needed to activate the coagulation factors II, VII, IX and X and the anticoagulation factors protein C and protein S, in which process it turns into vitamin K 2,3-epoxide. This is then recycled to vitamin K … See more Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting blood thinner drug to be taken by mouth, and a derivative of coumarin. It acts as a vitamin K antagonist and … See more Phenprocoumon is used for the prophylaxis and treatment of thromboembolic disorders after heart bypass surgery and myocardial infarction (heart attack), long-term treatment of myocardial infarction with increased risk of thromboembolism, See more Mild cases of overdosing are characterised by minor bleeding and/or bruising; they can usually be controlled by reducing the dose. … See more Phenprocoumon, a 4-hydroxycoumarin structurally similar to warfarin, is a white to off-white crystalline powder with a characteristic smell. It is practically insoluble in water, … See more Phenprocoumon is contraindicated when bleeding risks exceed the potential benefits, for example in people with severe bleeding diathesis, peptic ulcers, endocarditis See more The most common adverse effect is bleeding. It occurs in 5–25% of patients and ranges from harmless nosebleeds to life-threatening … See more Due to its narrow therapeutic index, the fact that it can only be eliminated from the body after inactivation by the liver enzymes CYP2C9 and CYP3A4, and its high plasma protein binding … See more WebDas 4-Hydroxycumarinderivat „Marcumar“ (Phenprocoumon) befindet sich seit dem Jahre 1953 als Anticoagulanz im Handel and nimmt z. Das 4-Hydroxycumarinderivat „Marcumar“ (Phenprocoumon) befindet sich seit dem Jahre 1953 als Anticoagulanz im Handel und nimmt z. Z. in Deutschland eine marktbeherrschende Stellung ein. Es ist erstaunlich, das … bread and butter pudding easy bbc

Phenprocoumon: Uses, Interactions, Mechanism of …

WebPhenprocoumon wird hauptsächlich von CYP2C9 und CYP3A4 metabolisiert. Zahlreiche weitere Wirkstoffe und Substanzen können die Wirkung verstärken oder abschwächen … WebJul 1, 1981 · The oxidation of the enantiomers of phenprocoumon catalyzed by noninduced rat hepatic microsomes was determined, and the formation of products was fou… WebPhenprocoumon belongs to the group of vitamin K antagonists (VKAs), for example warfarin and acenocoumarol. It is widely used for therapeutic anticoagulation and clinically … cory genelin